Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.6
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
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8
We investigated how systemic hyaluronic acid could aid in treating arthritis, particularly through intravenous use. This approach offers a viable alternative to traditional injections, especially for difficult-to-reach joints.
In our study with an arthritis mouse model, we found that hyaluronic acid gathered in inflamed joints, leading to noticeable reductions in swelling, redness, and other inflammatory markers. Despite these positive observations, it's important to note that overall results did not indicate a significant improvement in arthritis outcomes.
Nevertheless, our findings support further exploration of systemic hyaluronic acid as a potential treatment strategy.
In our study with an arthritis mouse model, we found that hyaluronic acid gathered in inflamed joints, leading to noticeable reductions in swelling, redness, and other inflammatory markers. Despite these positive observations, it's important to note that overall results did not indicate a significant improvement in arthritis outcomes.
Nevertheless, our findings support further exploration of systemic hyaluronic acid as a potential treatment strategy.
Read More
9
We explored a novel approach to treat rheumatoid arthritis using hyaluronic-acid-coated transethosomes loaded with tofacitinib. This method focuses on direct delivery to inflamed tissue, potentially reducing systemic side effects often seen with oral tofacitinib.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Read More
Most Useful Reviews
9
Joint pain relief
4 people found this helpful
I purchased this supplement as I suffer from rheumatoid arthritis. Initially, I was sceptical about its ability to relieve joint pain, but I was pleasantly surprised by the improvement I experienced in just two months. I hardly recall having any joint pain now and have already ordered more to ensure I don't run out!
Read More
9
Improved flexibility
2 people found this helpful
I am very satisfied with the results! A month later, the pain in my lower back, which I have endured with bending for over ten years, has vanished. I can bend and sit comfortably without any discomfort. My hands, which stiffened due to rheumatoid arthritis, are also functioning better. Additionally, the skin on my face has improved with fewer wrinkles, which is a pleasant surprise!
Read More
9
Eliminated painkillers
1 people found this helpful
I replaced my stronger painkillers with this product for my rheumatoid arthritis. I am thrilled to have discovered it and have been taking it every day. Though prices are higher elsewhere, it has made a noticeable difference.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.6
- All Researches
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
Read More
9
Novel RA treatment strategy explored
This study explored the potential of a new hyaluronic acid-modified nanocatalyst designed to treat rheumatoid arthritis (RA). The research aimed to manipulate immune cells in the body, specifically altering macrophage polarization and combating oxidative stress.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Read More
9
We explored a novel approach to treat rheumatoid arthritis using hyaluronic-acid-coated transethosomes loaded with tofacitinib. This method focuses on direct delivery to inflamed tissue, potentially reducing systemic side effects often seen with oral tofacitinib.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Our findings showed that these hyaluronic-acid formulations improved drug retention and demonstrated significant anti-inflammatory effects in animal models. Levels of key inflammatory markers decreased significantly after treatment, suggesting that this targeted therapy could effectively manage rheumatoid arthritis with fewer side effects compared to traditional methods.
Read More
9
Promising dual drug delivery strategy
We investigated a novel treatment for rheumatoid arthritis using hyalurosomes that combined dexamethasone and luteolin. This method showed promising results in reducing inflammation and joint swelling in a rat model.
Notably, histological evaluations revealed improvements in key inflammatory markers and overall joint health. However, while the findings are positive, it’s essential to recognize that these results stem from animal studies and may not directly translate to humans.
Notably, histological evaluations revealed improvements in key inflammatory markers and overall joint health. However, while the findings are positive, it’s essential to recognize that these results stem from animal studies and may not directly translate to humans.
Read More
9
We explored a new way to enhance rheumatoid arthritis treatment by developing a slow-release drug delivery system using hyaluronic acid microsponge (MSP) for methotrexate (MTX).
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
In preclinical studies, MSP maintained a controlled release of MTX, leading to nearly double the therapeutic effectiveness compared to traditional methods.
This innovative approach not only improved treatment outcomes but also aimed to reduce the adverse side effects usually linked with quick-release medications.
The findings suggest that this method could significantly benefit those suffering from rheumatoid arthritis.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Joint pain relief
4 people found this helpful
I purchased this supplement as I suffer from rheumatoid arthritis. Initially, I was sceptical about its ability to relieve joint pain, but I was pleasantly surprised by the improvement I experienced in just two months. I hardly recall having any joint pain now and have already ordered more to ensure I don't run out!
Read More
9
Improved flexibility
2 people found this helpful
I am very satisfied with the results! A month later, the pain in my lower back, which I have endured with bending for over ten years, has vanished. I can bend and sit comfortably without any discomfort. My hands, which stiffened due to rheumatoid arthritis, are also functioning better. Additionally, the skin on my face has improved with fewer wrinkles, which is a pleasant surprise!
Read More
9
Eliminated painkillers
1 people found this helpful
I replaced my stronger painkillers with this product for my rheumatoid arthritis. I am thrilled to have discovered it and have been taking it every day. Though prices are higher elsewhere, it has made a noticeable difference.
Read More
6
Significant pain relief
12 people found this helpful
My mother and I both drank this for about a month, combining it with collagen and MSM due to our joint pain from rheumatoid arthritis. We experienced significant pain relief. We're finishing the course and then transitioning to Natrol Cetyl Pure, before cycling back to this product. My skin has also become more supple and hydrated; however, it's difficult to pinpoint the exact benefits from singular products, as I've also included fish oil and calcium in my regimen. Regardless, the main result is remarkable!
Read More
9
Effective joint support
I have been using this for several years as preventive maintenance for my joints, having rheumatoid arthritis. It truly works and acts as a valuable support alongside my main treatment. I highly recommend this product.
Read More
Frequently Asked Questions
9
Improved flexibility
2 people found this helpful
I am very satisfied with the results! A month later, the pain in my lower back, which I have endured with bending for over ten years, has vanished. I can bend and sit comfortably without any discomfort. My hands, which stiffened due to rheumatoid arthritis, are also functioning better. Additionally, the skin on my face has improved with fewer wrinkles, which is a pleasant surprise!
6
Significant pain relief
12 people found this helpful
My mother and I both drank this for about a month, combining it with collagen and MSM due to our joint pain from rheumatoid arthritis. We experienced significant pain relief. We're finishing the course and then transitioning to Natrol Cetyl Pure, before cycling back to this product. My skin has also become more supple and hydrated; however, it's difficult to pinpoint the exact benefits from singular products, as I've also included fish oil and calcium in my regimen. Regardless, the main result is remarkable!
9
Notable results
I recommend this for rheumatoid arthritis as an excellent supplement! I am very pleased to have discovered it. After a course of 13 days, the results were quite noticeable. I plan to limit my next course to a maximum of 10 days as it is somewhat taxing on my body.
9
Joint pain relief
4 people found this helpful
I purchased this supplement as I suffer from rheumatoid arthritis. Initially, I was sceptical about its ability to relieve joint pain, but I was pleasantly surprised by the improvement I experienced in just two months. I hardly recall having any joint pain now and have already ordered more to ensure I don't run out!
9
Much reduced pain
I have rheumatoid arthritis pain in both knees. After taking these, I found that the pain is much reduced, and I will continue to use them according to the instructions on the bottle.
9
Knee pain relief
I regularly take rheumatoid arthritis supplements along with collagen and exercise at home on the orbit track. At 48, my knees feel great with this combination of sports. I consume two capsules after a meal, and they last a long time. These capsules contain chondroitin and hyaluronic acid, providing double benefits for my skin and hair. I also take collagen from the same brand, which I find very convenient. Ordering directly is more cost-effective with discounts, especially compared to the previous, pricier options I tried. My hair started to fall out after COVID, but with consistent use, not only have my knees improved, but also hair growth has been stimulated in areas of baldness. Thank you, Doctor Best!
9
Effective joint support
I have been using this for several years as preventive maintenance for my joints, having rheumatoid arthritis. It truly works and acts as a valuable support alongside my main treatment. I highly recommend this product.
9
Novel RA treatment strategy explored
This study explored the potential of a new hyaluronic acid-modified nanocatalyst designed to treat rheumatoid arthritis (RA). The research aimed to manipulate immune cells in the body, specifically altering macrophage polarization and combating oxidative stress.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
Through lab tests and experiments on mice, we found that the nanocatalyst effectively reduced joint inflammation and improved cartilage health. It also promoted a shift from harmful to protective immune responses. Overall, these findings suggest a promising approach to enhance RA treatment, combining multiple beneficial actions in one strategy.
9.5
We explored the impact of 35 kDa hyaluronic acid (HA35) fragments in relieving pain for a 58-year-old woman suffering from rheumatoid arthritis (RA) after mild COVID-19. Following initial treatments that led to side effects, she turned to a mixture of herbal and traditional medicine. While her widespread symptoms improved, localized joint pain persisted. After receiving HA35 injections, she experienced remarkable improvements, including full relief from elbow and knee pain. Our findings suggest HA35 could be an effective option for managing residual RA pain after conventional treatments.
9
We explored a new treatment for rheumatoid arthritis (RA) using hyaluronic acid-coated nanogels to deliver tacrolimus directly to inflamed joints. This innovative approach is designed to reduce the side effects commonly seen with traditional therapies. In our study, these nanogels showed improved targeting, leading to a notable decrease in inflammation and joint damage in animal models. The results suggest this targeted delivery system could enhance the efficacy of RA treatment while minimizing toxicity. Overall, this therapy holds promise for safer clinical applications in the future.
8
We explored how a new double-layered transdermal patch, combining 3D-printed hydrogels with nanofibers, may aid in treating rheumatoid arthritis (RA). This patch delivers hyaluronic acid and dexamethasone to target inflammation, achieving significant reductions in harmful cytokines. Additionally, our animal studies showed a remarkable improvement in joint health, with preserved tissue structure and less cell infiltration. Overall, while this innovative approach shows promise, further research is needed to fully understand its long-term benefits for RA patients.
References
- Zhang L, Wu G, Yao J, Wang D, Gao F, et al. Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis. Int J Biol Macromol. 2025;309:143143. doi:10.1016/j.ijbiomac.2025.143143
- Liu L, Ma X, Jia X, Hui JH, Hui M. Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report. Clin Case Rep. 2025;13:e70361. doi:10.1002/ccr3.70361
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. doi:10.1038/s41467-025-58059-z
- Šimek M, Rubanová D, Nešporová K, Skoroplyas S, Lehká K, et al. Pharmacokinetics of the systemic application of hyaluronic acid for joint arthritis treatment. Int J Biol Macromol. 2025;307:141937. doi:10.1016/j.ijbiomac.2025.141937
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. doi:10.1016/j.colsurfb.2025.114497
- Fiaschini N, Hanieh PN, Ariaudo D, Cimino R, Abbate C, et al. Application of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16121593
- Elshabrawy HA, Abo Dena AS, Sobhy MH, El-Sherbiny IM. Integrating 3D-printed hydrogels and polymeric nanofibers in a double-layered transdermal patch for the treatment of rheumatoid arthritis. RSC Adv. 2024;14:40187. doi:10.1039/d4ra07306a
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. doi:10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. doi:10.1186/s12951-024-02784-y
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. doi:10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. doi:10.1021/acs.biomac.4c00556
- Wang Y, Wang J, Ma M, Gao R, Wu Y, et al. Hyaluronic-Acid-Nanomedicine Hydrogel for Enhanced Treatment of Rheumatoid Arthritis by Mediating Macrophage-Synovial Fibroblast Cross-Talk. Biomater Res. 2024;28:0046. doi:10.34133/bmr.0046
